Michael Federle
Director, Center for Biomolecular Sciences
Professor, Pharmaceutical Sciences
Pharmaceutical Sciences
Contact
Building & Room:
MBRB 3072
Address:
900 S. Ashland Ave, Chicago, IL, 60607
Office Phone:
Email:
CV Link:
Related Sites:
Selected Publications
- Wilkening RV, Chang JC, Federle M. PepO, a CovRS-controlled endopeptidase, disrupts Streptococcus pyogenes quorum sensing. Mol Microbiol. 2016;99(1):71-87.
- Chang JC, Jimenez JC, Federle M. Induction of a quorum sensing pathway by environmental signals enhances group A streptococcal resistance to lysozyme. Mol Microbiol. 2015;97(6):1097-113.
- Parashar V, Aggarwal C, Federle M, Neiditch MB. Rgg protein structure-function and inhibition by cyclic peptide compounds. Proc Natl Acad Sci U S A. 2015;112(16):5177-82.
- Aggarwal CC, Jimenez Romaguera J, Lee HE, Chlipala G, Ratia K, Federle M. Identification of Quorum-Sensing Inhibitors Disrupting Signaling between Rgg and Short Hydrophobic Peptides in Streptococci.. mBio. 2015;6(3):e00393-15. doi:10.1128/mBio.00393-15.
- Aggarwal C, Jimenez JC, Nanavati D, Federle M. Multiple length peptide-pheromone variants produced by Streptococcus pyogenes directly bind Rgg proteins to confer transcriptional regulation. J Biol Chem. 2014;289(32):22427-36.
- Cook L, Federle M. Peptide pheromone signaling in Streptococcus and Enterococcus. FEMS Microbiol Rev. 2014;38(3):473-92.
- Jimenez JC, Federle M. Quorum sensing in group A Streptococcus. Front Cell Infect Microbiol. 2014;4:127.
- Marks LR, Mashburn-Warren L, Federle M, Hakansson AP. Streptococcus pyogenes biofilm growth in vitro and in vivo and its role in colonization, virulence, and genetic exchange. J Infect Dis. 2014;210(1):25-34.
- Lasarre B, Aggarwal C, Federle M. Antagonistic Rgg regulators mediate quorum sensing via competitive DNA binding in Streptococcus pyogenes. MBio. 2013;3(6).
- LaSarre B, Federle M. Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev. 2013;77(1):73-111.