Photo of Mankin, Shura

Shura Mankin

The Alexander Neyfahk Professor of Medicinal Chemistry and Pharmacognosy

Pharmaceutical Sciences

Contact

Building & Room:

3052 MBRB

Address:

900 S Ashland Avenue, Chicago, IL, 60607

Office Phone:

(312) 413-1406

Office Phone TTY:

(312) 413-9303

Email:

shura@uic.edu

CV Link:

Shura Mankin

Related Sites:

About

Mechanisms of protein synthesis; structure, function and evolution of ribosome and ribosomal RNA; mechanisms of action of ribosome-targeted antibiotics.

Selected Publications

  • Polikanov YS, Osterman IA, Szal TM, Tashlitsky VN, Serebryakova MV, Kusochek P, Bulkley D, Malanicheva IA, Efimenko TA, Efremenkova OV, Konevega AL, Shaw KJ, Bogdanov AA, Rodnina MV, Dontsova OA, Mankin A, Steitz TA, Sergiev PV. Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.. Molecular cell. 2014;56(4):531-40. doi:10.1016/j.molcel.2014.09.020.

 

  • Polikanov YS, Szal TM, Jiang F, Gupta P, Matsuda R, Shiozuka M, Steitz TA, Vázquez-Laslop N, Mankin A. Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA.. Molecular cell. 2014;56(4):541-50. doi:10.1016/j.molcel.2014.09.021.

 

  • Kannan K, Kanabar P, Schryer D, Florin T, Oh E, Bahroos N, Tenson T, Weissman JS, Mankin A. The general mode of translation inhibition by macrolide antibiotics.. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(45):15958-63. doi:10.1073/pnas.1417334111.

 

  • Sothiselvam S, Liu B, Han W, Ramu H, Klepacki D, Atkinson GC, Brauer A, Remm M, Tenson T, Schulten K, Vázquez-Laslop N, Mankin A. Macrolide antibiotics allosterically predispose the ribosome for translation arrest.. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(27):9804-9. doi:10.1073/pnas.1403586111.

 

  • Vázquez-Laslop N, Mankin A. Protein accounting in the cellular economy.. Cell. 2014;157(3):529-31. doi:10.1016/j.cell.2014.04.002.

 

  • Arenz S, Ramu H, Gupta P, Berninghausen O, Beckmann R, Vázquez-Laslop N, Mankin A, Wilson DN. Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide.. Nature communications. 2014;5:3501. doi:10.1038/ncomms4501.

 

  • Martínez AK, Gordon E, Sengupta A, Shirole N, Klepacki D, Martinez-Garriga B, Brown LM, Benedik MJ, Yanofsky C, Mankin A, Vazquez-Laslop NC, Sachs MS, Cruz-Vera LR. Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan.. Nucleic acids research. 2014;42(2):1245-56. doi:10.1093/nar/gkt923.

 

  • Gupta P, Kannan K, Mankin A, Vázquez-Laslop N. Regulation of gene expression by macrolide-induced ribosomal frameshifting.. Molecular cell. 2013;52(5):629-42. doi:10.1016/j.molcel.2013.10.013.

 

  • Orelle C, Carlson SN, Kaushal B, Almutairi MM, Liu H, Ochabowicz A, Quan S, Pham VC, Squires CL, Murphy BT, Mankin A. Tools for characterizing bacterial protein synthesis inhibitors.. Antimicrobial agents and chemotherapy. 2013;57(12):5994-6004. doi:10.1128/AAC.01673-13.

 

  • Orelle C, Szal TM, Klepacki D, Shaw KJ, Vázquez-Laslop N, Mankin A. Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition.. Nucleic acids research. 2013;41(14):e144. doi:10.1093/nar/gkt526.

 

Education

  • D.Sci, D.Sci, Moscow University,

  • PhD, , Moscow University,

  • MS, , Moscow University,