Mike E. Johnson
Professor Emeritus, Medicinal Chemistry and Pharmacognosy
Contact
Building & Room:
MBRB 3072
Address:
900 S. Ashland, Chicago, IL, 60607-7173
Office Phone:
Office Phone TTY:
Email:
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Selected Publications
- Lei HM, Jones CW, Zhu T, Patel KE, Wolf N, Fung L, Lee H, Johnson M. Identification of B. anthracis N5-carboxyaminoimidazole ribonucleotide mutase (PurE) active site binding compounds via fragment library screening.. Bioorganic & medicinal chemistry. 2015;. doi:10.1016/j.bmc.2015.12.029.
- McClay KD, Mehboob SL, Yu J, Santarsiero BE, Deng JJ, Cook J, Jeong H, Johnson M, Steffan R. Indole trimers with antibacterial activity against Gram-positive organisms produced using combinatorial biocatalysis.. AMB Express. 2015;5(1):125. doi:10.1186/s13568-015-0125-4.
- Rice AJ, Woo JK, Khan AZ, Szypulinski ME, Johnson M, Lee H, Lee H. Over-expression, purification, and confirmation of Bacillus anthracis transcriptional regulator NprR.. Protein expression and purification. 2015;. doi:10.1016/j.pep.2015.08.030.
- Lee H, Lei HD, Santarsiero BL, Gatuz JJ, Cao SZ, Rice AK, Patel KE, Szypulinski M, Ojeda I, Ghosh A, Johnson M. Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.. ACS chemical biology. 2015;10(6):1456-65. doi:10.1021/cb500917m.
- Mehboob SE, Song J, Hevener KL, Su PL, Boci TD, Brubaker LK, Truong LE, Mistry T, Deng J, Cook J, Santarsiero B, Ghosh A, Johnson M. Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI).. Bioorganic & medicinal chemistry letters. 2015;25(6):1292-6. doi:10.1016/j.bmcl.2015.01.048.
- Tuntland ML, Santarsiero BD, Johnson ME, Fung LW. Elucidation of the bicarbonate binding site and insights into the carboxylation mechanism of (N(5))-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis.. Acta crystallographica. Section D, Biological crystallography. 2014;70(Pt 11):3057-65. doi:10.1107/S1399004714021166.
- Zhang YY, Mehboob SH, Song JE, Boci TK, Johnson M, Ghosh A, Jeong H. Metabolism-directed structure optimization of benzimidazole-based Francisella tularensis enoyl-reductase (FabI) inhibitors.. Xenobiotica; the fate of foreign compounds in biological systems. 2014;44(5):404-16. doi:10.3109/00498254.2013.850553.
- Lee H, Mittal AL, Patel KC, Gatuz JE, Truong L, Torres J, Mulhearn D, Johnson M. Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings.. Bioorganic & medicinal chemistry. 2014;22(1):167-77. doi:10.1016/j.bmc.2013.11.041.
- Rice AJ, Truong LE, Johnson M, Lee H. A colorimetric assay optimization for high-throughput screening of dihydroorotase by detecting ureido groups.. Analytical biochemistry. 2013;441(1):87-94. doi:10.1016/j.ab.2013.05.035.
- Lee H, Cao SE, Hevener KL, Truong LK, Gatuz JE, Patel K, Ghosh A, Johnson M. Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications.. ChemMedChem. 2013;8(8):1361-72. doi:10.1002/cmdc.201300134.